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Preclinical characterization and comparison between CD3/CD19 bispecific and novel CD3/CD19/CD20 trispecific

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 139-149 doi: 10.1007/s11684-021-0835-8

Abstract: The CD19-targeting bispecific T-cell engager blinatumomab has shown remarkable efficacy in patients withBlinatumomab and A-319 are CD3/CD19 bispecific antibodies with different molecular sizes and structures, and A-2019 is a novel CD3/CD19/CD20 trispecific antibody with an additional anti-CD20 function.-319 demonstrated superior to that of A-2019, whereas A-2019 has an additional capability to target CD20in cells missing CD19, suggesting its potential function against CD19 weak or negative CD20 positive

Keywords： B-cell acute lymphoblastic leukemia     bispecific antibody     trispecific antibody     CD19     CD20    

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Clinical significance of CD34+CD117dim/CD34+CD117bri myeloblast-associated

Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 608-620 doi: 10.1007/s11684-021-0836-7

Abstract: Two leukemic myeloblast populations (CD34 CD117 and CD34 CD117 ) were previously identified in t(8;21Here, we examined the impact of CD34 CD117 /CD34 CD117 myeloblast-associated gene expression on t(8;The mRNA expression levels of CD34 CD117 -associated genes ( , , and ) and CD34 CD117 -associated genesUnivariate analysis revealed that CD19, CD34 CD117 proportion, mutation, minimal residual diseaseIdentifying the clinical relevance of CD34 CD117 /CD34 CD117 myeloblast-associated gene expression may

Keywords： t(8     21)(q22     q22) AML     CD34+CD117dim/ CD34+CD117bri cell population    

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Comparisons in subcellular and biochemical behaviors of cadmium between low-Cd and high-Cd accumulation

Meng XUE, Yihui ZHOU, Zhongyi YANG, Biyun LIN, Jiangang YUAN, Shanshan WU

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 2,   Pages 226-238 doi: 10.1007/s11783-013-0582-4

Abstract: in low-Cd accumulation cultivars and high-Cd accumulation cultivars of pakchoi ( L.).low-Cd cultivars.The high-Cd cultivars had significantly higher leaf and stem Cd concentrations than the low-Cd cultivarsthan high-Cd cultivars, leaf vacuole sequestrated higher proportions of Cd.Cd in the form of pectate/protein complexes (extracted by 1 mol·L NaCl) played a decisive role in Cd

Keywords： cadmium (Cd)     low-Cd cultivar     pakchoi (Brassica chinensis L.)    

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Nonlinear dynamic analysis of functionally graded carbon nanotube-reinforced composite plates using MISQ20

Frontiers of Structural and Civil Engineering   Pages 1072-1085 doi: 10.1007/s11709-023-0951-4

Abstract: objective of this study is to further extend the mixed integration smoothed quadrilateral element with 20unknowns of displacement (MISQ20) to investigate the nonlinear dynamic responses of functionally graded

Keywords： carbon nanotube     MISQ20     FG-CNTRC plate     nonlinear vibration     nonlinear dynamic analysis     SFEM    

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Rolling-element bearings in China: From ancient times to the 20th century

Lie SUN,Ang LI

Frontiers of Mechanical Engineering 2016, Volume 11, Issue 1,   Pages 33-43 doi: 10.1007/s11465-016-0373-2

Abstract:

The development of rolling-element bearings in China has spanned a long period. Based on several typical and important cases, the present article reconstructs the history of rolling-element bearings in China by dividing it into four stages according to the various characteristics of the bearings. The first stage represents the origin of rolling bearings in China, which remains controversial because of several suspected races and cages that were likely the components of bearings more than a millennium ago. At the second stage, a type of simple roller bearing was used for astronomical instruments not later than the 13th century based on clear philological and physical evidence. A similar bearing was also applied to an abridged armillary in the 17th century. Another type of spherical thrust bearings with rolling elements, which is a key component of a traditional Chinese windmill, could support a rotating shaft that moves rotationally and at an angle. At the third stage, the Chinese began studying and using the so-called European-style bearing since the 17th century. Moreover, over the last 100 years, the modern rolling bearing industry was gradually established in China, particularly because of the technology transfer from the Soviet Union in the 1950s. At the fourth stage, the Chinese government initiated the relatively rapid development of bearing technology. The government launched the “bearing movement” from the 1950s to the 1960s to establish the modern bearing industry and to promote rolling bearings as replacement for traditional sliding bearings. Furthermore, a number of large professional factories and institutions in China have continually introduced advanced technology and equipment. At present, these companies and institutions play a significant role in the international bearing industry.

Keywords： bearing movement     rolling-element bearing     China     early rolling bearings     technology transfer    

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20th Century" was Announced in Beijing"> "China’s Major Achievements in Engineering and Technology in the 20th Century" was Announced in Beijing

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Strategic Study of CAE 2002, Volume 4, Issue 1,   Pages 94-94

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Cultivars and oil extraction techniques affect Cd/Pb contents and health risks in oil of rapeseed grownon Cd/Pb-contaminated farmland

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 7, doi: 10.1007/s11783-023-1687-z

Abstract:

● Organic solvent extracted fewer Cd/Pb in rapeseed oil than physical

Keywords： Rapeseed oil     Oil extraction technologies     Human health risk assessment     Cd/Pb-contaminated farmland    

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Celecoxib in combination with retinoid CD437 inhibits melanoma A375 cell

Jianwen REN, Zhenhui PENG, Birong GUO, Min PAN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 108-112 doi: 10.1007/s11684-009-0015-8

Abstract: of celecoxib, synthetic retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid (CD437Both celecoxib and CD437 could inhibit the growth of human malignant melanoma A375 cells in a dose-dependentCelecoxib in combination with CD437 could significantly enhance the effects of inhibiting proliferationCD437 could inhibit the growth of human malignant melanoma A375 cells by inducing apoptosis and G /GCelecoxib exhibited additive effects with CD437 on retarding the growth and inducing apoptosis of human

Keywords： celecoxib     CD437     melanoma A375 cell     apoptosis     cycle arrest    

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ORGANIC CARBON STOCKS IN A SILTY TEXTURED SOIL FOLLOWING REINTEGRATION OF A 20 YEARS OLD × SITE INTO

Frontiers of Agricultural Science and Engineering 2023, Volume 10, Issue 2,   Pages 183-197 doi: 10.15302/J-FASE-2023485

Abstract:

● 0.98 Mg·ha−1·yr−1 Corg accumulation under miscanthus over 26 years.

Keywords： biobased energy crops     C balance     humus accumulation    

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Green building research from design to operation in the past 20 years: A perspective

Borong LIN, Yi WANG, Jiaping LIU, Juan YU

Frontiers of Structural and Civil Engineering 2020, Volume 14, Issue 5,   Pages 1049-1055 doi: 10.1007/s11709-020-0668-6

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Growth responses of the newly-discovered Cd-hyperaccumulator Rorippa globosa and its accumulation characteristicsof Cd and As under joint stress of Cd and As

SUN Yuebing, ZHOU Qixing, WEI Shuhe, REN Liping

Frontiers of Environmental Science & Engineering 2007, Volume 1, Issue 1,   Pages 107-113 doi: 10.1007/s11783-007-0020-6

Abstract: has been identified as a newly-found Cd-hyperaccumulating species.under joint stress of Cd and As.The results showed that Cd and As had an antagonistic effect on enhancing the growth of plants and Cdlevel under single Cd pollution.from a high concentration of Cd and As.

Keywords： synergic adverse     stress     present study     potential     weight    

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Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function ofCD19-specific CAR T-cells via TGF-β signaling

Frontiers of Medicine doi: 10.1007/s11684-023-1010-1

Abstract: Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function ofCD19-specific CAR T-cells via TGF-β signaling

Keywords： exosomes induce activation     impair function CD19     exosomal CD19 antigen    

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System Integration and Innovation of Operating 20 kt Combined Heavy-haul Train on Datong—Qinhuangdao

Geng Zhixiu

Strategic Study of CAE 2008, Volume 10, Issue 3,   Pages 31-43

Abstract: Relying on integration innovation, it succeeded in operating 20 kt-level combined heavy-haul train on

Keywords： China railways     Datong—Qinhuangdao line     20 kt-level combined heavy-haul train     integration innovation    

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Changes of phenotype and function of human CD4 CD25 T cells induced by transfection of Foxp3

WU Kui, BI Yutian, WANG Yaoli, WANG Changzheng

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 366-369 doi: 10.1007/s11684-008-0070-6

Abstract: Virus-containing supernatant was applied to differentiate CD4CD25 T cells.The effect of transfected CD4 T cells on the proliferation and cytokine production of CD4CD25 T cellsexpressions of CD25 and CTLA-4, but down-regulated CD127 expression.Transfected T cells inhibited the proliferation of CD4CD25 T cells.This suggested a key role of Foxp3 in the generation of CD4CD25 regulatory T cells.
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Alteration of heat shock protein 20 expression in preeclamptic patients and its effect in vascular and

Fanfan Li, Mengzhou He, Meitao Yang, Yao Fan, Yun Chen, Xi Xia, Yin Xie, Dongrui Deng

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 542-549 doi: 10.1007/s11684-017-0576-x

Abstract: Heat shock protein 20 (HSP20) is ubiquitously expressed under normal physiological conditions and hasHowever, the role of HSP20 in the pathogenesis of PE remains unclear.(CPAs) and serum from 118 healthy pregnant women and 80 women with PE and detected the levels of HSP20Both HSP20 and phosphorylated HSP20 were downregulated in CPAs from women with PE.HSP20 might contribute to the pathogenesis of PE.

Keywords： preeclampsia     heat shock protein 20     vascular relaxation     coagulation-fibrinolytic system    

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Title Author Date Type Operation

Preclinical characterization and comparison between CD3/CD19 bispecific and novel CD3/CD19/CD20 trispecific

Journal Article

Clinical significance of CD34+CD117dim/CD34+CD117bri myeloblast-associated

Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang

Journal Article

Comparisons in subcellular and biochemical behaviors of cadmium between low-Cd and high-Cd accumulation

Meng XUE, Yihui ZHOU, Zhongyi YANG, Biyun LIN, Jiangang YUAN, Shanshan WU

Journal Article

Nonlinear dynamic analysis of functionally graded carbon nanotube-reinforced composite plates using MISQ20

Journal Article

Rolling-element bearings in China: From ancient times to the 20th century

Lie SUN,Ang LI

Journal Article

"China’s Major Achievements in Engineering and Technology in the 20th Century" was Announced in Beijing

null

Journal Article

Cultivars and oil extraction techniques affect Cd/Pb contents and health risks in oil of rapeseed grownon Cd/Pb-contaminated farmland

Journal Article

Celecoxib in combination with retinoid CD437 inhibits melanoma A375 cell

Jianwen REN, Zhenhui PENG, Birong GUO, Min PAN

Journal Article

ORGANIC CARBON STOCKS IN A SILTY TEXTURED SOIL FOLLOWING REINTEGRATION OF A 20 YEARS OLD × SITE INTO

Journal Article

Green building research from design to operation in the past 20 years: A perspective

Borong LIN, Yi WANG, Jiaping LIU, Juan YU

Journal Article

Growth responses of the newly-discovered Cd-hyperaccumulator Rorippa globosa and its accumulation characteristicsof Cd and As under joint stress of Cd and As

SUN Yuebing, ZHOU Qixing, WEI Shuhe, REN Liping

Journal Article

Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function ofCD19-specific CAR T-cells via TGF-β signaling

Journal Article

System Integration and Innovation of Operating 20 kt Combined Heavy-haul Train on Datong—Qinhuangdao

Geng Zhixiu

Journal Article

Changes of phenotype and function of human CD4 CD25 T cells induced by transfection of Foxp3

WU Kui, BI Yutian, WANG Yaoli, WANG Changzheng

Journal Article

Alteration of heat shock protein 20 expression in preeclamptic patients and its effect in vascular and

Fanfan Li, Mengzhou He, Meitao Yang, Yao Fan, Yun Chen, Xi Xia, Yin Xie, Dongrui Deng

Journal Article